PRDM 2 ( PR domain containing 2 , with ZNF domain )
نویسندگان
چکیده
RIZ1 (280 kDa) and RIZ2 (260 kDa) differ only for the presence in the larger form (RIZ1) of the PR domain. In the sequence of both proteins have been identified several domains: PR domain (130 aa), endowed with histonemethyltransferase activity (Lys 9 of histone H3) and implicated in protein-protein interactions; E1A like-domain (100 aa), contains the LXCXE sequence able to interact with the oncosupressor gene Rb; Two zinc-finger clusters; Proline-rich domain, containing a LXXLL motif mediating the interaction with estrogen receptor.
منابع مشابه
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تاریخ انتشار 2011